The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Type II secretion system (T2SS), domain F

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Type II secretion system (T2SS), domain F

This superfamily consists of bacterial proteins involved in a general secretion pathway (GSP) for the export of proteins (also called the type II pathway) PMID:8438237. These are proteins of about 400 amino acids that are highly hydrophobic and which are thought to be integral protein of the inner membrane. This domain consists of a bundle of six anti-parallel helices and has a novel fold PMID:19324092. Proteins with this domain form a platform for the type II secretion machinery, as well as the type IV pili and the archaeal flagellae PMID:11266368.

According to Pfam, the original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it.


GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
12087 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 11
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 7
Unique EC:
Unique GO: 10
Unique Species: 12087