The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

M75 peptidase, HXXE motif

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: M75 peptidase, HXXE motif

The superfamily includes the imelysin peptidase, a M75 peptidase first identified in Pseudomonas aeruginosa and Algp7, a cell-surface alginate-binding protein, that was characterised in Sphingomonas sp. A1 and functions as a concentrator of the polysaccharide in the cell-surface pit. His201 and Glu204 are completely conserved in M75 and occur in an HXXE motif that is also found in family M14.

Based on the primary structure and genetic organisation in the bacterial genome, Algp7 was found to be homologous to an M75 peptidase motif-containing EfeO, a component of a ferrous ion transporter. Although a metal-binding motif, HxxE, conserved in zinc ion-dependent M75 peptidases is also found in Algp7, the crystal structure of Algp7 contains no metal even at the motif. The protein consists of two structurally similar up-and-down helical bundles as the basic scaffold. A deep cleft between the bundles is sufficiently large to accommodate macromolecules such as alginate polysaccharide PMID:21238429., PFAM:PF09375

GO Diversity

Unique GO annotations
6 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
4051 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 9
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC:
Unique GO: 6
Unique Species: 4051