The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Effector protein HopAB, BAK1-interacting domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Effector protein HopAB, BAK1-interacting domain

Structural domains comprising this superfamily share the structure of the BAK1 binding domain found in members of the HopAB family of proteins. These are type III effector proteins that are secreted by the plant pathogen Pseudomonas syringae into the host plant to inhibit its immune system and facilitate the spread of the pathogen PMID:15808932. The best studied member of this family, HopAB3/AvrPtoB, suppresses host basal defenses by interfering with PAMP (pathogen-associated molecular signature)-triggered immunity (PTI) by the binding and inhibiton of BAK1, a kinase which serves to activate defense signaling PMID:22169508. It also recognizes the kinase Pto to activate effector-triggered immunity (ETI) PMID:21112235.

HopAB3 contains an N-terminal region comprised of two kinase-interacting domains (KID) and a C-terminal E3 ligase domain. The first KID recognizes the PTI-associated kinase Bti9 as well as Pto, and is referred to as the Pto-binding domain (PID). The second KID interacts with BAK1 and FLS2, which are leucine-rich repeat-containing receptor-like kinases, and is called the BAK1-interacting domain (BID) PMID:22169508,PMID:19062288.

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
27 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 3
Unique Species: 27