The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Large T antigen, SV40, domain 3

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Large T antigen, SV40, domain 3

This superfamily is made up of 7 alpha helices, and in the context of SV40, this superfamily is not made up of a contiguous polypeptide chain.

SV40 is made up of domains 1, 2 and 3.

This superfamily makes up domain 3, the only domain which plays no role in the multimerisation to form the hexameric form of large T antigen. Instead, domain 3 plays a role in p53 binding and binding polymerase machinery, evidenced by the protein's inability to bind p53 if certain mutations are introduced into domain 3.

GO Diversity

Unique GO annotations
6 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
131 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 39
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 11
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 6
Unique Species: 131