The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Alpha-glycerophosphate oxidase, cap domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Alpha-glycerophosphate oxidase, cap domain

Alpha-glycerophosphate oxidase, also known as glycerol-3-phosphate dehydrogenase (GlpD) is an essential membrane enzyme which functions at the central junction of respiration, glycolysis, and phospholipid biosynthesis. Its critical role is indicated by the multitiered regulatory mechanisms that stringently controls its expression and function. Homologs of GlpD are found in practically all organisms, from prokaryotes to humans.

Structural domains comprising this superfamily share the structure of the C-terminal cap domain of alpha-glycerophosphate oxidase which shows an overall negative electrostatic surface, believed to aid in substrate recognition. The positive electrostatic potential of the base of the FAD-domain delineates the regions that interacts with the negative phospholipid head groups of the membrane bilayer. The distinct electrostatic "polarity" of these distal regions are likely involved in the establishment of a proper alignment of GlpD into the membrane bilayer PMID:18296637,PMID:18154320.

GO Diversity

Unique GO annotations
28 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
8178 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 14
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 3
Unique PDBs: 8
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 26
Unique EC: 3
Unique GO: 28
Unique Species: 8178