This superfamily entry consists of programmed cell death protein 5 (PDCD5) found in archaea and eukaryota, which contain a predicted DNA-binding domain PMID:11017201 and may function as DNA-binding proteins. Methanobacterium thermoautotrophicum MTH1615 was predicted to bind DNA based on structural proteomics data, and this was confirmed by the demonstration that it can interact non-specifically with a randomly chosen 20-mer of double stranded DNA PMID:11017201. The human programmed cell death protein 5 (PDCD5, formerly known as TFAR19, TF-1 cell apoptosis-related gene 19) is a well-conserved protein, which shares significant homology to the corresponding proteins of species ranging from yeast to mice. PDCD5 exhibits a ubiquitous expression pattern and its expression is up-regulated in the tumour cells undergoing apoptosis. PDCD5 may play a general role in the apoptotic process. Experimental evidence suggests that charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein PMID:9920759,PMID:19358820.

PFAM:PF01984, INTERPRO:IPR036883,DOI:10.1038/82823,DOI:10.1016/j.abb.2009.03.018