The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:


Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PDCD5, DNA-binding domain

This superfamily entry consists of programmed cell death protein 5 (PDCD5) found in archaea and eukaryota, which contain a predicted DNA-binding domain PMID:11017201 and may function as DNA-binding proteins. Methanobacterium thermoautotrophicum MTH1615 was predicted to bind DNA based on structural proteomics data, and this was confirmed by the demonstration that it can interact non-specifically with a randomly chosen 20-mer of double stranded DNA PMID:11017201. The human programmed cell death protein 5 (PDCD5, formerly known as TFAR19, TF-1 cell apoptosis-related gene 19) is a well-conserved protein, which shares significant homology to the corresponding proteins of species ranging from yeast to mice. PDCD5 exhibits a ubiquitous expression pattern and its expression is up-regulated in the tumour cells undergoing apoptosis. PDCD5 may play a general role in the apoptotic process. Experimental evidence suggests that charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein PMID:9920759,PMID:19358820.

PFAM:PF01984, INTERPRO:IPR036883,DOI:10.1038/82823,DOI:10.1016/

GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
2070 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 4
Unique PDBs: 6
Structural Clusters (5A): 2
Structural Clusters (9A): 2
FunFam Clusters: 24
Unique EC:
Unique GO: 24
Unique Species: 2070