×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 1.10.730.10

Isoleucyl-tRNA Synthetase; Domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Isoleucyl-tRNA Synthetase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Arginine--tRNA ligase
350 - - 75.1
3
Leucine--tRNA ligase
295
3D
 4cqnD04 - 84.9
2
Leucine--tRNA ligase
288 - - 98.5
4
Isoleucyl-tRNA synthetase, cytoplasmic
267 - - 92.5
5
Methionine--tRNA ligase
258
3D
 3h9cA03 - 91.3
6
Arginyl-tRNA synthetase 2, mitochondrial
229
3D
 1f7vA02 - 98.2
7
Valine--tRNA ligase
223 - - 77.5
8
Arginine--tRNA ligase
175
3D
 2zufA03 - 98.1
9
Valine--tRNA ligase, mitochondrial
167 - - 94.5
10
methionine--tRNA ligase, cytoplasmic
156 - - 85.2
11
Leucine--tRNA ligase chloroplastic/mitochondrial
152 - - 96.9
12
Leucine--tRNA ligase
143 - - 93.3
13
leucine--tRNA ligase, cytoplasmic
127 - - 52.6
14
Valine--tRNA ligase
125 - - 91.4
15
Valine--tRNA ligase
120 - - 78.0
16
Arginine--tRNA ligase, cytoplasmic
114 - - 74.3
17
Arginine--tRNA ligase, chloroplastic/mitochondrial
109 - - 71.2
18
Leucine--tRNA ligase
107 - - 70.0
19
Valine--tRNA ligase, mitochondrial
99 - - 86.6
82
Methionyl-tRNA synthetase, putative
92
3D
 5v49B03 - 63.8
21
Isoleucine--tRNA ligase
87 - - 63.1
20
Leucine--tRNA ligase cytoplasmic
87 - - 93.4
22
Methionyl-tRNA synthetase 2, mitochondrial
78 - - 96.3
23
probable leucine--tRNA ligase, mitochondrial
68 - - 85.9
25
Isoleucine--tRNA ligase cytoplasmic
64 - - 74.4
24
Methionine--tRNA ligase cytoplasmic
64 - - 78.9
26
Methionine--tRNA ligase
57 - - 93.2
27
Valine--tRNA ligase
46 - - 73.1
28
Methionine--tRNA ligase, chloroplastic/mitochondrial
44 - - 74.7
29
Leucine--tRNA ligase
43 - - 43.3
31
Putative Methionyl-tRNA synthetase
39 - - 94.6
30
Methionine--tRNA ligase
39 - - 53.7
33
Valine--tRNA ligase
34 - - 97.6
35
Methionine--tRNA ligase
34
3D
 6ax8A03 - 68.8
32
Leucine--tRNA ligase, putative
34 - - 17.9
34
Arginine--tRNA ligase
33 - - 10.8
36
Isoleucine--tRNA ligase
28 - - 26.3
38
Isoleucine--tRNA ligase
26 - - 80.7
37
Methionyl-tRNA synthetase
26 - - 93.9
39
Arginine--tRNA ligase
24 - - 27.0
41
Methionine--tRNA ligase
23 - - 22.6
40
Methionyl-tRNA synthetase, cytoplasmic, putative
23 - - 82.2
43
Methionine-tRNA ligase
23
3D
 2ct8B03 - 81.0
42
Leucine--tRNA ligase, putative
19 - - 9.6
44
Methionine--tRNA ligase, putative
18 - - 13.6
45
Leucyl-tRNA synthetase
17 - - 54.2
47
Arginine-tRNA ligase
16 - - 24.5
51
Leucine--tRNA ligase
16
3D
 1wz2B03 - 87.9
46
Leucine--tRNA ligase
16 - - 0.8
48
Arginine--tRNA ligase, putative
15 - - 12.2
49
Leucine--tRNA ligase
15 - - 0.0
50
Isoleucine-tRNA ligase, putative
15 - - 15.5
53
Leucine--tRNA ligase
13 - - 57.1
52
Valine-tRNA ligase
13 - - 0.0
54
Valine--tRNA ligase
12 - - 2.6
55
Methionine--tRNA ligase
12 - - 0.0
63
Mitochondrial methionyl-tRNA synthetase
11 - - 37.5
59
Arginine-tRNA ligase
11 - - 8.5
56
Leucine--tRNA ligase
11 - - 0.0
64
Probable arginine--tRNA ligase, cytoplasmic
11 - - 86.7
62
Putative methionyl-tRNA synthetase
11 - - 36.6
58
Leucine-tRNA ligase, putative
11 - - 5.4
57
Leucine--tRNA ligase
11 - - 0.0
60
Leucyl-tRNA synthetase
11 - - 79.1
61
Valyl-tRNA synthetase, isoform A
11 - - 8.7
69
Isoleucyl-tRNA synthetase, putative
10 - - 59.0
66
Isoleucine--tRNA ligase
10 - - 0.0
68
Methionyl-tRNA synthetase
10 - - 3.7
65
Leucyl-tRNA synthetase
10 - - 67.9
67
Leucine--tRNA ligase
10 - - 25.5
73
Isoleucine--tRNA ligase, cytoplasmic
9 - - 30.3
72
Leucyl-tRNA synthetase
9 - - 66.6
71
Arginine--tRNA ligase
9 - - 10.1
70
Arginine-tRNA ligase, putative
9 - - 1.9
79
Isoleucyl-tRNA synthetase, cytoplasmic, putative
7 - - 0.0
76
Leucyl-tRNA synthetase, cytoplasmic, putative
7 - - 3.9
80
Isoleucine--tRNA ligase
7 - - 3.1
74
Nam2p
7 - - 7.9
81
Leucine--tRNA ligase
7 - - 9.7
83
Isoleucine--tRNA ligase
7 - - 77.5
78
Methionine--tRNA ligase, cytoplasmic
7 - - 10.5
75
Putative leucyl-tRNA synthetase
7 - - 72.5
84
Leucyl-tRNA synthetase b
7 - - 62.0
77
Arginine--tRNA ligase
7 - - 13.4
88
Leucine--tRNA ligase, mitochondrial
6 - - 37.5
92
GD12953
6 - - 77.5
85
Leucyl-tRNA synthetase 2, mitochondrial
6 - - 88.0
90
Methionine--tRNA ligase
6 - - 21.9
87
probable arginine--tRNA ligase, cytoplasmic
6 - - 12.2
91
Methionine--tRNA ligase
6 - - 1.5
89
Isoleucine--tRNA ligase
6 - - 21.7
86
Leucine--tRNA ligase
6 - - 54.2
98
Leucine--tRNA ligase, mitochondrial
5 - - 11.9
100
Leucine--tRNA ligase
5 - - 13.0
105
Isoleucyl-tRNA synthetase
5 - - 11.2
95
Leucine--tRNA ligase
5 - - 0.0
101
Isoleucine--tRNA ligase protein
5 - - 6.0
103
GM25865
5 - - 14.2
97
Arginine--tRNA ligase
5 - - 0.0
104
Methionine-tRNA ligase
5 - - 10.1
99
LD44376p
5 - - 0.0
93
Methionine--tRNA ligase
5 - - 10.5
106
Methionine--tRNA ligase
5 - - 0.9
102
Valine--tRNA ligase
5 - - 61.0
107
Protein CBG19783
5 - - 57.4
96
Arginine--tRNA ligase, cytoplasmic
5 - - 6.9
94
Leucine--tRNA ligase
5 - - 1.0
110
Leucine--tRNA ligase
4 - - 4.0
115
Methionyl-tRNA synthetase
4 - - 46.2
113
Valyl-tRNA synthetase 2, mitochondrial
putative
4 - - 9.4
111
Probable valine--tRNA ligase, mitochondrial
4 - - 63.6
114
Valine--tRNA ligase
4 - - 5.2
116
Methionine--tRNA ligase, mitochondrial
4 - - 10.0
112
Valine--tRNA ligase
4 - - 0.0
109
Arginine--tRNA ligase
4 - - 8.7
117
Mitochondrial probable methionyl-tRNA synthetase
4 - - 2.5
108
Leucyl Amino-acyl tRNA Synthetase
4 - - 85.5
118
Methionine--tRNA ligase
4 - - 5.2
124
Leucyl-tRNA synthetase
3 - - 0.0
121
Arginine--tRNA ligase
3 - - 3.0
123
Leucine--tRNA ligase
3 - - 0.0
132
Leucyl-tRNA synthetase 2, mitochondrial
3 - - 0.0
125
Leucine--tRNA ligase
3 - - 1.3
120
Leucine--tRNA ligase, cytoplasmic
3 - - 35.1
128
Methionine-tRNA synthetase, putative
3 - - 1.9
134
Uncharacterized protein
3 - - 27.9
131
Valyl Amino-acyl tRNA Synthetase
3 - - 18.2
129
Methionine--tRNA ligase
3 - - 0.0
127
Methionine--tRNA ligase
3 - - 35.4
133
Probable methionine--tRNA ligase, mitochondrial
3 - - 61.8
126
Valine--tRNA ligase
3 - - 0.6
122
Leucine--tRNA ligase
3 - - 0.0
119
Valyl tRNA synthetase putative
3 - - 0.0
130
Leucine--tRNA ligase
3 - - 63.7
166
Methionine--tRNA ligase
2 - - 0.0
153
Valyl tRNA Synthetase
2 - - 0.0
138
Leucine--tRNA ligase
2 - - 0.0
162
Methionyl-tRNA synthetase
2 - - 1.3
170
Methionine--tRNA ligase
2 - - 0.0
151
Leucyl-tRNA synthetase
2 - - 0.0
142
AGAP004708-PA
2 - - 9.0
137
Uncharacterized protein
2 - - 0.0
139
Leucine--tRNA ligase
2 - - 0.0
154
Leucine--tRNA ligase
2 - - 0.0
146
Arginine--tRNA ligase
2 - - 0.0
175
Arginine--tRNA ligase
2 - - 41.0
150
Valyl tRNA Synthetase
2 - - 0.0
171
Methionine--tRNA ligase
2 - - 0.0
147
Arginine--tRNA ligase
2 - - 7.1
149
Valyl tRNA Synthetase
2 - - 43.2
173
Uncharacterized protein
2 - - 39.2
168
Leucine--tRNA ligase
2 - - 10.8
136
Leucyl-tRNA synthetase 2, mitochondrial
2 - - 0.0
155
Leucyl-tRNA synthetase
AFU_orthologue AFUA_6G04910
2 - - 0.0
174
Uncharacterized protein
2 - - 41.6
167
Leucine--tRNA ligase
2 - - 0.7
169
Leucine--tRNA ligase
2 - - 0.0
148
Putative leucine--tRNA ligase, mitochondrial-like Protein
2 - - 59.7
165
Isoleucine--tRNA ligase
2 - - 0.0
140
Uncharacterized protein
2 - - 12.4
157
Leucine--tRNA ligase, mitochondrial
2 - - 34.5
159
Uncharacterized protein
2 - - 0.0
145
Uncharacterized protein
2 - - 3.4
160
Methionine-tRNA ligase
2 - - 0.0
176
DALR anticodon binding domain containing protein
2 - - 43.5
172
Valine--tRNA ligase
2 - - 38.7
158
Putative arginine--tRNA ligase, mitochondrial
2 - - 0.0
164
Isoleucine--tRNA ligase
2 - - 5.7
143
Arginine--tRNA ligase
2 - - 5.4
141
YALI0E24607p
2 - - 0.0
135
Methionine--tRNA ligase
2 - - 0.0
163
Methionine--tRNA ligase
2 - - 0.0
152
Valyl tRNA Synthetase, putative
2 - - 1.6
144
Arginine--tRNA ligase
2 - - 0.0
156
Leucine--tRNA ligase
2 - - 0.0
161
YALI0D03619p
2 - - 0.0
209
Valine--tRNA ligase, mitochondrial
1 - - 0.0
198
Arginine--tRNA ligase
1 - - 0.0
207
Uncharacterized protein
1 - - 0.0
222
Uncharacterized protein
1 - - 0.0
217
Putative leucine--tRNA ligase CDC60
1 - - 0.0
219
Valyl-tRNA synthetase
1 - - 0.0
184
AER043Cp
1 - - 0.0
235
Methionine--tRNA ligase
1 - - 0.0
226
Probable methionine--tRNA ligase, mitochondrial
1 - - 0.0
181
Uncharacterized protein
1 - - 0.0
199
Predicted protein
1 - - 0.0
197
Uncharacterized protein
1 - - 0.0
208
Uncharacterized protein
1 - - 0.0
230
Uncharacterized protein
1 - - 0.0
183
Uncharacterized protein
1 - - 0.0
218
Uncharacterized protein
1 - - 0.0
228
Uncharacterized protein
1 - - 0.0
185
Uncharacterized protein
1 - - 0.0
234
Methionine--tRNA ligase
1 - - 0.0
196
Uncharacterized protein
1 - - 0.0
192
Uncharacterized protein
1 - - 0.0
229
Uncharacterized protein
1 - - 0.0
227
Methionine--tRNA ligase
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
231
Uncharacterized protein
1 - - 0.0
216
Valyl-tRNA synthetase
1 - - 0.0
233
Valyl tRNA Synthetase, putative
1 - - 0.0
202
Arginine--tRNA ligase
1 - - 0.0
206
Uncharacterized protein
1 - - 0.0
180
Uncharacterized protein
1 - - 0.0
201
Arginyl-tRNA synthetase, putative
1 - - 0.0
188
Leucine--tRNA ligase subunit beta
1 - - 0.0
213
Protein CBR-LARS-2
1 - - 0.0
194
Uncharacterized protein
1 - - 0.0
236
Uncharacterized protein
1 - - 0.0
225
Valine--tRNA ligase
1 - - 0.0
211
Predicted protein
1 - - 0.0
203
Valyl tRNA Synthetase
1 - - 0.0
232
Uncharacterized protein
1 - - 0.0
187
Leucine--tRNA ligase
1 - - 0.0
189
Glycine--tRNA ligase beta subunit
1 - - 0.0
214
Valyl-tRNA synthetase
1 - - 0.0
191
Uncharacterized protein
1 - - 0.0
193
Arginyl-tRNA synthetase, putative
1 - - 0.0
204
Uncharacterized protein
1 - - 0.0
220
Leucine--tRNA ligase
1 - - 0.0
210
Valine--tRNA ligase
1 - - 0.0
177
Leucyl-tRNA synthetase 2, mitochondrial
1 - - 0.0
179
Uncharacterized protein
1 - - 0.0
182
Leucyl Amino-acyl tRNA Synthetase
1 - - 0.0
200
Uncharacterized protein
1 - - 0.0
224
Os06g0645400 protein
1 - - 0.0
195
Leucyl-tRNA synthetase
1 - - 0.0
186
Valine--tRNA ligase
1 - - 0.0
221
Valyl-tRNA synthetase 2, mitochondrial
1 - - 0.0
178
Leucine--tRNA ligase
1 - - 0.0
215
Uncharacterized protein
1 - - 0.0
237
Methionine--tRNA ligase
1 - - 0.0
190
Uncharacterized protein
1 - - 0.0
205
Protein CBR-LARS-2
1 - - 0.0
223
Uncharacterized protein
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...