The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Set2, Rpb1 interacting domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Set2, Rpb1 interacting domain

According to the literature, members of the structural domains which comprise this superfamily correspond to the structure of the Rpb1 interacting domain of Set2. Rpb1 is the largest subunit of RNA polymerase II and elongation is influenced by the phosphorylation status of its C-terminal domain. Set2, a histone methyltransferase involved in the modification of K36 of histone H3 in nucleosomes of transcribed genes, interacts with the hyperphosphorylated C-terminal domain by virtue of its Rpb1 interacting domain which, in consequence, acts to couple histone H3 K36 methylation with transcript elongation PMID:16314571

GO Diversity

Unique GO annotations
58 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1050 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 8
Unique EC: 1
Unique GO: 58
Unique Species: 1050