The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Immunodeficiency lentiviruses, gag gene matrix protein p17

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Immunodeficiency lentiviruses, gag gene matrix protein p17

The matrix protein forms an icosahedral shell associated with the inner membrane of the mature immunodeficiency virus.

Retroviral matrix proteins (or major core proteins) are components of envelope-associated capsids, which line the inner surface of virus envelopes and are associated with viral membranes PMID:9657938. Matrix proteins are produced as part of Gag precursor polyproteins. During viral maturation, the Gag polyprotein is cleaved into major structural proteins by the viral protease, yielding the matrix (MA), capsid (CA), nucleocapsid (NC), and some smaller peptides. Gag-derived proteins govern the entire assembly and release of the virus particles, with matrix proteins playing key roles in Gag stability, capsid assembly, transport and budding. Although matrix proteins from different retroviruses appear to perform similar functions and can have similar structural folds, their primary sequences can be very different.

This entry represents matrix proteins from immunodeficiency lentiviruses, such as Human immunodeficiency virus (HIV) and Simian immunodeficiency virus (SIV-cpz) PMID:12465460. The structure of the HIV protein consists of 5 alpha helices, a short 3.10 helix and a 3-stranded mixed beta-sheet PMID:7966331.


GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
7 Unique EC terms

Species Diversity

Unique species annotations
430 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 34
Domain clusters (>95% seq id): 10
Domain clusters (>35% seq id): 6
Unique PDBs: 27
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC: 7
Unique GO: 24
Unique Species: 430