The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

TGS-like domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Obg-related GTPase Ych/YyaF, coiled-coil domain

Purine nucleotide-binding proteins build the large family of P-loop GTPases and related ATPases, which perform essential functions in all kingdoms of life. The Obg family comprises a group of ancient GTPases belonging to the TRAFAC (for translation factors) class. The Obg protein family is thought to comprise five ancient subfamilies, namely Obg/CgtA, YchF/YyaF, Drg/Rbg, Nog1, and Ygr210. Structural analysis of yeast and bacterial YchF revealed a modular organization formed by three domains, a central G domain, flanked by a coiled-coil domain and a TGS (ThrRS, GTPase, SpoT) domain PMID:17430889.

Only a few reports touch on the biological functions of YchF proteins and most focus on human and microorganisms. The YchF proteins may play a role in iron utilization and regulation of the Ton system in Brucella melitensis, and in the growth of the procyclic forms of Trypanosoma cruzi. The human YchF homolog hOLA1 suppresses cellular oxidative responses but enhances heat shock responses. In plants, we have shown that rice (OsYchF1) and Arabidopsis (AtYchF1) YchF proteins function as negative regulators in both abiotic stress responses and plant-defense responses PMID:26912459.

PMID:17430889 PMID:26912459

GO Diversity

Unique GO annotations
32 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
13401 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 13
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 3
Unique PDBs: 9
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 9
Unique EC:
Unique GO: 32
Unique Species: 13401