The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

ISWI, HAND domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ISWI, HAND domain

According to the literature, members of the structural domains which comprise this superfamily correspond to the structure of the C-terminal domain of the nucleosome remodelling ATPase ISWI. which in InterPro is annotated as ISWI, HAND domain (INTERPRO:IPR036306). The reason behind this designation lies on the fact that this domain resembles the structure of an open hand. This domain provides ISWI with both DNA and nucleosome binding properties.

GO Diversity

Unique GO annotations
97 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1288 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 5
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 4
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 14
Unique EC:
Unique GO: 97
Unique Species: 1288