The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Integrase, N-terminal zinc-binding domain

Retroviral integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains: an N-terminal zinc binding domain, a central catalytic core and a C-terminal DNA-binding domain. It is often found as part of the POL polyprotein. This entry represents a structural domain with an alpha-helical, orthogonal bundle fold. Domains with this structure are found at the N-terminal (zinc-binding domain) of HIV integrase, and in the following hypothetical proteins: YebC from Escherichia coli, HP0162 from Helicobacter pylori (Campylobacter pylori) and aq1575 from Aquifex aeolicus.

PMID:11743009 PMID:11101216 PMID:12060744

GO Diversity

Unique GO annotations
28 Unique GO terms

EC Diversity

Unique EC annotations
8 Unique EC terms

Species Diversity

Unique species annotations
14609 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 61
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 5
Unique PDBs: 17
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 15
Unique EC: 8
Unique GO: 28
Unique Species: 14609