The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

BFD-like [2Fe-2S]-binding domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: BFD-like [2Fe-2S]-binding domain

The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as bacterioferritin-associated ferredoxin (BFD, P13655). The function of BFD is not known, but it may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria PMID:8639572. This domain is also found in nitrate reductase proteins in association with the nitrite and sulphite reductase 4Fe-4S domain (PFAM:PF01077, INTERPRO:IPR006067), nitrite/sulphite reductase ferredoxin-like half domain (PFAM:PF03460, INTERPRO:IPR005117). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N-terminal domain (PFAM:PF00070, INTERPRO:IPR002871) and C-terminal domain (PFAM:PF01106, INTERPRO:IPR001075).


GO Diversity

Unique GO annotations
22 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
10804 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 10
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 3
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 21
Unique EC: 4
Unique GO: 22
Unique Species: 10804