The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

IrrE, HTH domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: IrrE, HTH domain

This superfamily entry represents the HTH (helix-turn-helix) central domain from the metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae PMID:19150362. It is folded in a three-helix bundle, with the second and third helices forming the HTH motif. The IrrE HTH domain shows a high level of structural similarity to HTH domains of the Lrp/AsnC transcriptional regulatory family, although it is not located as expected at either C- or N- termini of the protein. Its central location (residues 126-167) was suggested to endow it with some specific properties PMID:19150362.

This domain is also found in HTH-type transcriptional regulators RamB PMID:15090522 and PrpC PMID:22916289. The entry also includes the catalytic domain of the protein ImmA (MEROPS identifier M78.001), a metallopeptidase containing an HEXXH zinc-binding motif.


GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
23 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC:
Unique GO:
Unique Species: 23