CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.250.890
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P56568
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P56568
RIP1_LUFAE
Luffa aegyptiaca
Ribosome-inactivating protein luffin P1

PDB Structure

PDB 6O3S
External Links
Method SOLUTION NMR
Organism
Primary Citation
An Ancient Peptide Family Buried within Vicilin Precursors.
Zhang, J., Payne, C.D., Pouvreau, B., Schaefer, H., Fisher, M.F., Taylor, N.L., Berkowitz, O., Whelan, J., Rosengren, K.J., Mylne, J.S.
Acs Chem.Biol.
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