CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family |
Enzyme Information
| 3.4.21.34 |
Plasma kallikrein.
based on mapping to UniProt P03952
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
-!- Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. -!- Activates coagulation factors XII, VII and plasminogen. -!- Selective for Arg > Lys in P1, in small molecule substrates. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.21 and EC 3.4.21.8.
|
UniProtKB Entries (1)
| P03952 |
KLKB1_HUMAN
Homo sapiens
Plasma kallikrein
|
PDB Structure
| PDB | 6O1S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition.
J.Struct.Biol.
|
