1 keywords

CATH Domain 6nxzA00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.30 Roll
Topology 2.30.30 SH3 type barrels.
Homologous Superfamily 2.30.30.60  

Domain Context

CATH Clusters

Superfamily 2.30.30.60
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00383
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00383
DYR21_ECOLX
Escherichia coli
Dihydrofolate reductase type 2

PDB Structure

PDB 6NXZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
Toulouse, J.L., Yachnin, B.J., Ruediger, E.H., Deon, D., Gagnon, M., Saint-Jacques, K., Ebert, M.C.C.J.C., Forge, D., Bastien, D., Colin, D.Y., Vanden Eynde, J.J., Marinier, A., Berghuis, A.M., Pelletier, J.N.
Acs Omega