CATH Domain 6nqaK01

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.260	434 Repressor (Amino-terminal Domain)
	1.10.260.60

Domain Context

CATH Clusters

Superfamily	1.10.260.60
Functional Family	Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q8TEK3

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (2)

Q8TEK3	DOT1L_HUMAN Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific
P02281	H2B11_XENLA Xenopus laevis Histone H2B 1.1

PDB Structure

PDB	6NQA
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Worden, E.J., Hoffmann, N.A., Hicks, C.W., Wolberger, C. Cell