CATH Domain 6npiB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.390	Epstein Barr virus nuclear antigen-1, DNA-binding domain

Domain Context

CATH Clusters

Superfamily	Epstein Barr virus nuclear antigen-1, DNA-binding domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

EBNA1_EBVB9

Human herpesvirus 4 strain B95-8

Epstein-Barr nuclear antigen 1

PDB Structure

PDB	6NPI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth. Messick, T.E., Smith, G.R., Soldan, S.S., McDonnell, M.E., Deakyne, J.S., Malecka, K.A., Tolvinski, L., van den Heuvel, A.P.J., Gu, B.W., Cassel, J.A., Tran, D.H., Wassermann, B.R., Zhang, Y., Velvadapu, V., Zartler, E.R., Busson, P., Reitz, A.B., Lieberman, P.M. Sci Transl Med