CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Estradiol 17-beta-dehydrogenase 1

Enzyme Information

1.1.1.62
17-beta-estradiol 17-dehydrogenase.
based on mapping to UniProt P14061
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
-!- The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids. -!- The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270. -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).

UniProtKB Entries (1)

P14061
DHB1_HUMAN
Homo sapiens
Estradiol 17-beta-dehydrogenase 1

PDB Structure

PDB 6MNC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition.
Li, T., Stephen, P., Zhu, D.W., Shi, R., Lin, S.X.
Febs J.