CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | NADP-dependent L-serine/L-allo-threonine dehydrogenase |
Enzyme Information
| 1.1.1.313 |
Sulfoacetaldehyde reductase.
based on mapping to UniProt D3U1D9
Isethionate + NADP(+) = 2-sulfoacetaldehyde + NADPH.
-!- Catalyzes the reaction only in the opposite direction. -!- Involved in taurine degradation. -!- The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyze this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). -!- The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells.
|
UniProtKB Entries (1)
| D3U1D9 |
ISFD_KLEOX
Klebsiella oxytoca
Sulfoacetaldehyde reductase
|
PDB Structure
| PDB | 6IXJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Biochemical and structural investigation of sulfoacetaldehyde reductase fromKlebsiella oxytoca.
Biochem. J.
|