CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.330
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q9UNP9
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62306
RUXF_HUMAN
Homo sapiens
Small nuclear ribonucleoprotein F

PDB Structure

PDB 6ID0
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structures of the human spliceosomes before and after release of the ligated exon.
Zhang, X., Zhan, X., Yan, C., Zhang, W., Liu, D., Lei, J., Shi, Y.
Cell Res.