CATH Classification

Domain Context

CATH Clusters

Superfamily Cathepsin C, exclusion domain
Functional Family Dipeptidyl peptidase 1

Enzyme Information

3.4.14.1
Dipeptidyl-peptidase I.
based on mapping to UniProt P53634
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.
-!- Also polymerizes dipeptide amides, arylamides and esters at neutral pH. -!- Cl(-)-dependent lysosomal cysteine-type peptidase. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.9.

UniProtKB Entries (1)

P53634
CATC_HUMAN
Homo sapiens
Dipeptidyl peptidase 1

PDB Structure

PDB 6IC5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.
Korkmaz, B., Lesner, A., Wysocka, M., Gieldon, A., Hakansson, M., Gauthier, F., Logan, D.T., Jenne, D.E., Lauritzen, C., Pedersen, J.
Biochem. Pharmacol.