CATH Domain 6i8tA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt P26446

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt P26446

UniProtKB Entries (1)

P26446

PARP1_CHICK

Gallus gallus

Poly [ADP-ribose] polymerase 1

PDB Structure

PDB	6I8T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. Papeo, G., Orsini, P., Avanzi, N.R., Borghi, D., Casale, E., Ciomei, M., Cirla, A., Desperati, V., Donati, D., Felder, E.R., Galvani, A., Guanci, M., Isacchi, A., Posteri, H., Rainoldi, S., Riccardi-Sirtori, F., Scolaro, A., Montagnoli, A. Acs Med.Chem.Lett.