CATH Domain 6hh3A00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.4080	ADP-ribosylglycohydrolase fold
	1.10.4080.10	ADP-ribosylation/Crystallin J1

Domain Context

CATH Clusters

Superfamily	ADP-ribosylation/Crystallin J1
Functional Family	ADP-ribose glycohydrolase ARH3

Enzyme Information

3.2.1.143	Poly(ADP-ribose) glycohydrolase. based on mapping to UniProt H3BCW1 Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose- ribose bond to produce free ADP-D-ribose. -!- Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-D- ribose).
3.5.1.-	In linear amides. based on mapping to UniProt H3BCW1
3.2.2.-	Hydrolyzing N-glycosyl compounds. based on mapping to UniProt H3BCW1

UniProtKB Entries (1)

ARHL2_LATCH

Latimeria chalumnae

ADP-ribose glycohydrolase ARH3

PDB Structure

PDB	6HH3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Rack, J.G.M., Ariza, A., Drown, B.S., Henfrey, C., Bartlett, E., Shirai, T., Hergenrother, P.J., Ahel, I. Cell Chem Biol