CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q04771
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q04771
ACVR1_HUMAN
Homo sapiens
Activin receptor type-1

PDB Structure

PDB 6GIN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept.
Hudson, L., Mui, J., Vazquez, S., Carvalho, D.M., Williams, E., Jones, C., Bullock, A.N., Hoelder, S.
J. Med. Chem.