CATH Classification

Domain Context

CATH Clusters

Superfamily Neutral endopeptidase , domain2
Functional Family Membrane metalloendopeptidase

Enzyme Information

3.4.24.11
Neprilysin.
based on mapping to UniProt P08473
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
-!- A membrane-bound glycoprotein widely distributed in animal tissues. -!- Inhibited by phosphoramidon and thiorphan. -!- Belongs to peptidase family M13.

UniProtKB Entries (1)

P08473
NEP_HUMAN
Homo sapiens
Neprilysin

PDB Structure

PDB 6GID
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High resolution crystal structure of substrate-free human neprilysin.
Moss, S., Subramanian, V., Acharya, K.R.
J. Struct. Biol.