CATH Domain 6g94J00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.645	Cytochrome-c3 Hydrogenase; chain B
	1.10.645.10	Cytochrome-c3 Hydrogenase, chain B

Domain Context

CATH Clusters

Superfamily	Cytochrome-c3 Hydrogenase, chain B
Functional Family	Hydrogenase 2 large subunit

Enzyme Information

1.12.99.6

Hydrogenase (acceptor).

based on mapping to UniProt P0ACD8

H(2) + A = AH(2).

-!- Uses molecular hydrogen for the reduction of a variety of substances.

UniProtKB Entries (3)

P0ACD8	MBHL_ECOLI Escherichia coli K-12 Hydrogenase-1 large chain
P69740	MBHS_ECOL6 Escherichia coli CFT073 Hydrogenase-1 small chain
P0AAM2	CYBH_ECO57 Escherichia coli O157:H7 Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit

PDB Structure

PDB	6G94
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray structural, functional and computational studies of the O2-sensitive E. coli hydrogenase-1 C19G variant reveal an unusual [4Fe-4S] cluster. Volbeda, A., Mouesca, J.M., Darnault, C., Roessler, M.M., Parkin, A., Armstrong, F.A., Fontecilla-Camps, J.C. Chem. Commun. (Camb.)