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1 keywords

CATH Domain 6fypA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.200 Phosphorylase Kinase; domain 1
Homologous Superfamily 3.30.200.20 Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Dual specificity protein kinase CLK2

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P49761
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P49761
CLK3_HUMAN
Homo sapiens
Dual specificity protein kinase CLK3

PDB Structure

PDB 6FYP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.
Kallen, J., Bergsdorf, C., Arnaud, B., Bernhard, M., Brichet, M., Cobos-Correa, A., Elhajouji, A., Freuler, F., Galimberti, I., Guibourdenche, C., Haenni, S., Holzinger, S., Hunziker, J., Izaac, A., Kaufmann, M., Leder, L., Martus, H.J., von Matt, P., Polyakov, V., Roethlisberger, P., Roma, G., Stiefl, N., Uteng, M., Lerchner, A.
ChemMedChem
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