CATH Domain 6fj2A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.390	Neutral Protease; domain 2
	1.10.390.10	Neutral Protease Domain 2

Domain Context

CATH Clusters

Superfamily	Neutral Protease Domain 2
Functional Family	Thermolysin

Enzyme Information

3.4.24.27

Thermolysin.

based on mapping to UniProt P00800

Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.

-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (1)

P00800

THER_BACTH

Bacillus thermoproteolyticus

Thermolysin

PDB Structure

PDB	6FJ2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	ID30B - a versatile beamline for macromolecular crystallography experiments at the ESRF. McCarthy, A.A., Barrett, R., Beteva, A., Caserotto, H., Dobias, F., Felisaz, F., Giraud, T., Guijarro, M., Janocha, R., Khadrouche, A., Lentini, M., Leonard, G.A., Lopez Marrero, M., Malbet-Monaco, S., McSweeney, S., Nurizzo, D., Papp, G., Rossi, C., Sinoir, J., Sorez, C., Surr, J., Svensson, O., Zander, U., Cipriani, F., Theveneau, P., Mueller-Dieckmann, C. J Synchrotron Radiat