CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q9Y3C6
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q8IYB3
SRRM1_HUMAN
Homo sapiens
Serine/arginine repetitive matrix protein 1

PDB Structure

PDB 6FF4
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Haselbach, D., Komarov, I., Agafonov, D.E., Hartmuth, K., Graf, B., Dybkov, O., Urlaub, H., Kastner, B., Luhrmann, R., Stark, H.
Cell