CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.370
Functional Family DNA polymerase I

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P19821
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P19821
DPO1_THEAQ
Thermus aquaticus
DNA polymerase I, thermostable

PDB Structure

PDB 6FBG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Kropp, H.M., Durr, S.L., Peter, C., Diederichs, K., Marx, A.
Proc. Natl. Acad. Sci. U.S.A.