CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Furin 2, isoform B

Enzyme Information

3.4.21.75
Furin.
based on mapping to UniProt P09958
Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
-!- Activated by calcium. -!- Belongs to peptidase family S8.

UniProtKB Entries (1)

P09958
FURIN_HUMAN
Homo sapiens
Furin

PDB Structure

PDB 6EQV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Dahms, S.O., Hardes, K., Steinmetzer, T., Than, M.E.
Biochemistry