CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family Chalcone synthase 2

Enzyme Information

2.3.1.74
Chalcone synthase.
based on mapping to UniProt P13114
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2).
-!- The enzyme catalyzes the first committed step in the biosynthesis of flavonoids. -!- It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.

UniProtKB Entries (1)

P13114
CHSY_ARATH
Arabidopsis thaliana
Chalcone synthase

PDB Structure

PDB 6DXB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants.
Liou, G., Chiang, Y.C., Wang, Y., Weng, J.K.
J. Biol. Chem.