CATH Domain 6db2A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.130	Double-stranded beta-helix
	3.60.130.10	Clavaminate synthase-like

Domain Context

CATH Clusters

Superfamily	Clavaminate synthase-like
Functional Family	Alpha-ketoglutarate-dependent L-arginine hydroxylase

Enzyme Information

1.14.11.41

L-arginine hydroxylase.

based on mapping to UniProt Q6WZB0

L-arginine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-arginine + succinate + CO(2).

-!- The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. -!- It differs from EC 1.14.20.7, because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine.

UniProtKB Entries (1)

Q6WZB0

ARGHX_STRVI

Streptomyces vinaceus

Alpha-ketoglutarate-dependent L-arginine hydroxylase

PDB Structure

PDB	6DB2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of alpha-Heteroatom Assistance. Dunham, N.P., Chang, W.C., Mitchell, A.J., Martinie, R.J., Zhang, B., Bergman, J.A., Rajakovich, L.J., Wang, B., Silakov, A., Krebs, C., Boal, A.K., Bollinger, J.M. J. Am. Chem. Soc.