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1 keywords

CATH Domain 6cqwB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1820 alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Acetylcholinesterase

Enzyme Information

3.1.1.7
Acetylcholinesterase.
based on mapping to UniProt P22303
Acetylcholine + H(2)O = choline + acetate.
-!- Acts on a variety of acetic esters. -!- Also catalyzes transacetylations.

UniProtKB Entries (1)

P22303
ACES_HUMAN
Homo sapiens
Acetylcholinesterase

PDB Structure

PDB 6CQW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.
Bester, S.M., Guelta, M.A., Cheung, J., Winemiller, M.D., Bae, S.Y., Myslinski, J., Pegan, S.D., Height, J.J.
Chem. Res. Toxicol.
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