CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | O-methyltransferase ZRP4 |
Enzyme Information
| 2.1.1.150 |
Isoflavone 7-O-methyltransferase.
based on mapping to UniProt O24529
S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 7-methoxyisoflavone.
-!- The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones.
|
UniProtKB Entries (1)
| O24529 |
7OMT8_MEDSA
Medicago sativa
Isoflavone-7-O-methyltransferase 8
|
PDB Structure
| PDB | 6CIG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.
Nat. Struct. Biol.
|
