CATH Domain 6bq0B00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Monoglyceride lipase

Enzyme Information

3.1.1.23

Acylglycerol lipase.

based on mapping to UniProt Q99685

Hydrolyzes glycerol monoesters of long-chain fatty acids.

UniProtKB Entries (1)

MGLL_HUMAN

Homo sapiens

Monoglyceride lipase

PDB Structure

PDB	6BQ0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. McAllister, L.A., Butler, C.R., Mente, S., O'Neil, S.V., Fonseca, K.R., Piro, J.R., Cianfrogna, J.A., Foley, T.L., Gilbert, A.M., Harris, A.R., Helal, C.J., Johnson, D.S., Montgomery, J.I., Nason, D.M., Noell, S., Pandit, J., Rogers, B.N., Samad, T.A., Shaffer, C.L., da Silva, R.G., Uccello, D.P., Webb, D., Brodney, M.A. J. Med. Chem.