CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450-Terp, domain 2
Functional Family Citrate synthase

Enzyme Information

2.3.3.16
Citrate synthase (unknown stereospecificity).
based on mapping to UniProt B0YD89
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.
-!- This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C(2) of oxaloacetate has not been established (cf. EC 2.3.3.1 and EC 2.3.3.3).
2.3.3.5
2-methylcitrate synthase.
based on mapping to UniProt B0YD89
Propanoyl-CoA + H(2)O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3- tricarboxylate + CoA.
-!- The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. -!- The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1. -!- Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate. -!- Formerly EC 4.1.3.31.

UniProtKB Entries (1)

B0YD89
PRPC_ASPFC
Aspergillus fumigatus A1163
2-methylcitrate synthase, mitochondrial

PDB Structure

PDB 6BOL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of mtuant 2-methylcitrate synthase mcsAG419A from Aspergillus fumigatus.
Schlachter, C.R., Chruszcz, M.
To Be Published