CATH Classification

Domain Context

CATH Clusters

Superfamily Haem peroxidase domain superfamily, animal type
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt Q05769
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

Q05769
PGH2_MOUSE
Mus musculus
Prostaglandin G/H synthase 2

PDB Structure

PDB 6BL4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.
Xu, S., Uddin, M.J., Banerjee, S., Duggan, K., Musee, J., Kiefer, J.R., Ghebreselasie, K., Rouzer, C.A., Marnett, L.J.
J.Biol.Chem.