CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.940.10
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q8RQE7
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q8RQE9
RPOB_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit beta

PDB Structure

PDB 6ASG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Lin, W., Das, K., Degen, D., Mazumder, A., Duchi, D., Wang, D., Ebright, Y.W., Ebright, R.Y., Sineva, E., Gigliotti, M., Srivastava, A., Mandal, S., Jiang, Y., Liu, Y., Yin, R., Zhang, Z., Eng, E.T., Thomas, D., Donadio, S., Zhang, H., Zhang, C., Kapanidis, A.N., Ebright, R.H.
Mol. Cell