CATH Domain 6ahsA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.117

Stratum corneum chymotryptic enzyme.

based on mapping to UniProt Q91VE3

Cleavage of proteins with aromatic side chains in the P1 position.

-!- This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. -!- It cleaves the B chain of bovine insulin at 6-Leu-|-Cya-7 (cysteic acid), 16-Tyr-|-Leu-17, 25-Phe-|-Tyr-26 and 26-Tyr-|-Thr-27. -!- It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

Q91VE3

KLK7_MOUSE

Mus musculus

Kallikrein-7

PDB Structure

PDB	6AHS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors. Murafuji, H., Muto, T., Goto, M., Imajo, S., Sugawara, H., Oyama, Y., Minamitsuji, Y., Miyazaki, S., Murai, K., Fujioka, H. Bioorg. Med. Chem. Lett.