CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family DNA-directed DNA/RNA polymerase mu

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9NP87
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9NP87
DPOLM_HUMAN
Homo sapiens
DNA-directed DNA/RNA polymerase mu

PDB Structure

PDB 6AEC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
Chang, Y.K., Huang, Y.P., Liu, X.X., Ko, T.P., Bessho, Y., Kawano, Y., Maestre-Reyna, M., Wu, W.J., Tsai, M.D.
J.Am.Chem.Soc.