CATH Domain 5zqqB00

CATH Classification

Level	CATH Code	Description
	6	Special
	6.20	Other non-globular
	6.20.320	YefM-like fold
	6.20.320.10

Domain Context

CATH Clusters

Superfamily	6.20.320.10
Functional Family

Enzyme Information

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt Q9H2K2

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt Q9H2K2

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q9H2K2

TNKS2_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase tankyrase-2

PDB Structure

PDB	5ZQQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. Shirai, F., Tsumura, T., Yashiroda, Y., Yuki, H., Niwa, H., Sato, S., Chikada, T., Koda, Y., Washizuka, K., Yoshimoto, N., Abe, M., Onuki, T., Mazaki, Y., Hirama, C., Fukami, T., Watanabe, H., Honma, T., Umehara, T., Shirouzu, M., Okue, M., Kano, Y., Watanabe, T., Kitamura, K., Shitara, E., Muramatsu, Y., Yoshida, H., Mizutani, A., Seimiya, H., Yoshida, M., Koyama, H. J. Med. Chem.