CATH Classification

Domain Context

CATH Clusters

Superfamily NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
Functional Family NADH-quinone oxidoreductase subunit A

Enzyme Information

7.1.1.2
NADH:ubiquinone reductase (H(+)-translocating).
based on mapping to UniProt P03897
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
-!- The complex is present in mitochondria and aerobic bacteria. -!- Breakdown of the complex can release EC 1.6.99.3. -!- In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH. -!- Formerly EC 1.6.5.3.

UniProtKB Entries (1)

P03901
NU4LM_HUMAN
Homo sapiens
NADH-ubiquinone oxidoreductase chain 4L

PDB Structure

PDB 5XTD
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
Guo, R., Zong, S., Wu, M., Gu, J., Yang, M.
Cell