CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome-c3 Hydrogenase, chain B
Functional Family NADH-quinone oxidoreductase subunit D

Enzyme Information

7.1.1.2
NADH:ubiquinone reductase (H(+)-translocating).
based on mapping to UniProt O75306
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
-!- The complex is present in mitochondria and aerobic bacteria. -!- Breakdown of the complex can release EC 1.6.99.3. -!- In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH. -!- Formerly EC 1.6.5.3.
1.6.99.3
NADH dehydrogenase.
based on mapping to UniProt O75306
NADH + acceptor = NAD(+) + reduced acceptor.
-!- After preparations have been subjected to certain treatments cytochrome c may act as acceptor. -!- Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. -!- Present in a mitochondrial complex as EC 7.1.1.2. -!- Formerly EC 1.6.2.1.

UniProtKB Entries (1)

P03901
NU4LM_HUMAN
Homo sapiens
NADH-ubiquinone oxidoreductase chain 4L

PDB Structure

PDB 5XTD
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
Guo, R., Zong, S., Wu, M., Gu, J., Yang, M.
Cell