CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P9WKE5
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P9WKE5
KPYK_MYCTU
Mycobacterium tuberculosis H37Rv
Pyruvate kinase

PDB Structure

PDB 5WS8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Zhong, W., Cui, L., Goh, B.C., Cai, Q., Ho, P., Chionh, Y.H., Yuan, M., Sahili, A.E., Fothergill-Gilmore, L.A., Walkinshaw, M.D., Lescar, J., Dedon, P.C.
Nat Commun