CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Acetolactate synthase

Enzyme Information

2.2.1.6
Acetolactate synthase.
based on mapping to UniProt P07342
2 pyruvate = 2-acetolactate + CO(2).
-!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18.

UniProtKB Entries (1)

P07342
ILVB_YEAST
Saccharomyces cerevisiae S288C
Acetolactate synthase catalytic subunit, mitochondrial

PDB Structure

PDB 5WKC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into the mechanism of inhibition of AHAS by herbicides.
Lonhienne, T., Garcia, M.D., Pierens, G., Mobli, M., Nouwens, A., Guddat, L.W.
Proc. Natl. Acad. Sci. U.S.A.