CATH Classification

Domain Context

CATH Clusters

Superfamily Ras guanine-nucleotide exchange factors catalytic domain
Functional Family son of sevenless homolog 1 isoform X2

Enzyme Information

UniProtKB Entries (1)

Q07889
SOS1_HUMAN
Homo sapiens
Son of sevenless homolog 1

PDB Structure

PDB 5WFQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Burns, M.C., Howes, J.E., Sun, Q., Little, A.J., Camper, D.V., Abbott, J.R., Phan, J., Lee, T., Waterson, A.G., Rossanese, O.W., Fesik, S.W.
Anal. Biochem.