CATH Domain 5webA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.91	Restriction Endonuclease
	3.40.91.90	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

Domain Context

CATH Clusters

Superfamily	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

C3W5S0_I09A0

Influenza A virus (A/California/04/2009(H1N1))

Polymerase acidic protein

PDB Structure

PDB	5WEB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Beylkin, D., Kumar, G., Zhou, W., Park, J., Jeevan, T., Lagisetti, C., Harfoot, R., Webby, R.J., White, S.W., Webb, T.R. Sci Rep